Symantec Mail Security for Exchange v4.5 on clusters
I am working on a project for the U.S. Army. We had planned on using Symantec Mail Security for Exchange (SMSMSE) (v4.5) as the antivirus software package for the servers. We found that SMSMSE does not work properly on Exchange 2003 clusters with more than two nodes. The bottom line is that SMSMSE cannot work as a clustered resource. Symantec's Premier support did not seem to concerned that it would not work in our environment.
Sigh.... sorry, I'm ranting. I usually like Symantec's products. But, if you have any cluster configuration other than a two-node, active-passive cluster, you should consider using Sybari's Antigen. This will save you a lot of time and trouble when trying to make your cluster work well.
If you have no choice but to use SMSMSE on your clustered nodes, it will have to be installed on each node and not operated as a clustered resource.